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Canagliflozin reduces plasma uremic toxins and alters the intestinal microbiota composition in a chronic kidney disease mouse model

In the early 1940s, Arthur Kornberg identified an enzyme nicotinamide mononucleotide adenylyltransferase (NMNAT) in NAD+s biosynthesis pathway

Furthermore, the associations between gut solute paracellular permeability and circulating endotoxin concentrations should not be regarded as cause and effect, but rather increased gut paracellular permeability should be regarded as a useful biomarker for systemic inflammation

R., Spitzer, D., Goedegebuure, P., Mach, R