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Because rapid correction of severe B12 deficiency can trigger a surge in bone marrow activity and red blood cell production

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doi: 10.1515/jtim-2015-0002 3 Ruiz-PostigoJAJainSMadjouSVirrey AguaJFMaia-ElkhouryANValadasSet al

This is well illustrated by the velocity equation for the CBS reaction, the first step in the transsulfuration pathway: The first factor is simply Michaelis-Menten kinetics for the CBS reaction that uses homocysteine (Hcy) and serine (Ser) as substrates

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Because of its chemical alteration and the amino acid changes, IGF-1 L[R3] can avoid binding to proteins in the human body and so to have a much longer half life, around 20-30 hours