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The D4 report captures recommendations developed during the SACCs December 2025 peer review of the EPAs draft risk evaluation and released by the EPA this month, in which the SACC says the EPAs D4 draft evaluation is directionally sound in places but incomplete and urges the EPA to broaden exposure assessment, improve environmental-release analysis, and strengthen documentation before issuing a final risk evaluation determining whether D4 presents an unreasonable risk under TSCA

The most common adverse effects are gastrointestinal in nature, including nausea, stomach upset, or mild diarrhea

The regulatory framework for research compounds requires institutions to maintain records of compound acquisition, storage, use and disposal

1723-1734 [Wiley] 34

Remove the water and you eliminate these degradation pathways almost entirely

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