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However, supplementing cell-permeable dimethyl succinate (DM-succinate) at similar doses to -KG failed to rescue any cell death (Extended Data Fig

His passion for science and spirit of collaboration will be profoundly missed

Similar to curcumin, quercetin suffers from poor oral bioavailability, primarily due to its low water solubility, rapid metabolism, and limited intestinal absorption

Moreover, this effect was conserved even in the presence of pro-apototic cytokines, suggesting that it may play a dominant role, even within the context of an active inflammation[156]

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Following endocytosis, Fe is reduced to Fe by the six-transmembrane epithelial antigen of the prostate 3 (STEAP3), and subsequently stored in mitochondria, the endoplasmic reticulum, ferritin, and the iron pool