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Clinical trials of GLP-1-based medications have shown average reductions ranging from moderate to significant percentages of total body weight when combined with dietary changes

Most patients begin to notice symptom relief within a few days of starting the treatment, especially in cases of fatigue and mild neuropathy

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In the withdrawal trial, participants switched to placebo regained about 14% over the following year. Tapering, protein at roughly 0.7 g per pound, resistance training, and follow-up reduce the risk, but no post-stop protocol guarantees maintenance

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