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Arch Neurol

Effects may be faster with medical-grade B12 and professional dosing

Summary of Key Points What: B injections are vitamin B12 delivered IM/SC (usually 1000 g/mL)

A deficiency may cause hair loss, but extra B12 only helps if levels are low

Resources We Trust Cleveland Clinic: A Nutritional Plan for Anyone Living With Crohns Disease or Ulcerative Colitis Mayo Clinic: Anemia American Society of Hematology: Patient Groups Crohns & Colitis Foundation: Join the Community Crohns Colitis Canada: Fatigue Anemia Fact Sheet

Cell-culture (3T3-L1 adipocytes) 5-Amino-1MQ at 30 M strongly reduced 1-MNA levels in mouse fat cells, confirming NNMT inhibition (Neelakantan et al., Biochemical Pharmacology, 2018)