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Class IIa HDACs can shuttle between the nucleus and cytoplasm following diverse cell signal stress while the distributions of class IIb HDACs are mainly detected in the cytoplasm [57]

Given that LA is a necessary cofactor for mitochondrial -ketoacid dehydrogenases, it thus serves a critical role in mitochondrial energy metabolism

10.1371/journal.pone.0020700 48 DavidB