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The compounding effect of improved liver function and enhanced fat metabolism becomes more apparent

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The protective effects of ALCAR reported may occur by several mechanisms, including a general anti-inflammatory effect, activation of the Nrf2/antioxidant response, or support of oxidative metabolism by providing acetyl moieties to the TCA cycle, thereby bypassing the enzyme pyruvate dehydrogenase that is vulnerable to oxidative damage [31]

Therefore, in consideration of the prior request discussed in FY 2022 rulemaking and to further explore this current finding, we examined claims data from the September 2022 update of the FY 2022 MedPAR file for MS-DRGs 246, 247, 248, and 249 for all other cases assigned to MS-DRGs 246, 247, 248, and 249 that did not report percutaneous coronary IVL as reflected in the previous table