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Lau, David C W
The main pharmacological effects and underlying mechanism of action of rutin contribute to its antioxidant capacity through the Nrf2/ARE and anti-inflammatory properties due to NF-B, COX-2, IL-6, and TNF- suppression
By targeting multiple pathways involved in appetite regulation, energy balance, and glucose metabolism, this combination could offer superior efficacy compared to single-agent therapies
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Thus, GSH and ATF4 levels in CML cells are the markers to indicate JMF4073 sensitivity and determine the selection of GSH blocker for the combination with JMF4073 in therapy
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