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Cytostatic agents, particularly platinum-based drugs such as topotecan and cisplatin, have been linked to the induction of eryptosis, thereby worsening anemia [392, 393]

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MDR1, also known as permeability glycoprotein ( P-gp ), is a transmembrane transport protein that recognizes and controls drug efflux from tumor tissues and eventually promotes drug resistance in breast cancer by altering drug distribution in tumors 52