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To model Leydig cell senescence in vitro, TM3 mouse Leydig cells were treated with hydrogen peroxide (H2O2)

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Thus, as oxidation of Hb occurs, even under normal physiological conditions, the antioxidant defenses have a crucial role in the regeneration of functional Hb and maintenance of low metHb levels [11]

This channel is the one directly affected by the Category 1/Category 2 decision

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The enzymatic mechanism mainly involves lipoxygenase (LOX) and cytochrome P450 oxidoreductase (POR)