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APE1 co-precipitates more with nucleophosmin (NPM1) in C9orf72 patient tissue lysates compared to controls (Farg et al., 2017), and overexpression of NPM1 inhibits apoptosis in neuronal cells expressing poly GR 100 and poly PR 100 (Farg et al., 2017)

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It offers a promising approach for designing allele-specific DNAzymes capable of selectively targeting mutant mRNA rather than the wild type 8

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The peptide's extraordinary potency, active at concentrations seven orders of magnitude lower than BDNF itself, suggests highly specific receptor interactions rather than broad pharmacological effects

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Additionally, we evaluated the therapeutic effects of Snakebite Capsules on ferroptosis-related indicators, clarifying their mechanism in mitigating venom toxicity

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