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It activates the tyrosine kinase activity of IGF-1 receptor (IGF-1R), induces downstream MAPK/ERK and PI3K/Akt pathways, promotes the expression of cell cycle proteins (Cyclin D1, E), and accelerates the transition of cells from G1 phase to Sphase

, Figure 3B ), we re-fit the locus term as a random effect and then calculate best linear unbiased estimates (BLUPs) of m , which conservatively constrains potentially unstable fixed effect regression coefficients

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