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In many other forms of arthritis, only the joints are affected

Agomelatine (activity at the serotonin-2C receptor) functions as an anti-depressant, ramelteon (selective MT1/MT2 agonist) is marketed for use in sleep onset insomnia, tasimelteon (MT1/MT2 agonist), is commercialized for the treatment of circadian rhythm disorders particularly non-24h sleep wake disorder (113, 114)

In the past twenty years, and mainly by repurposing drugs use, molecules have been identified but to date, clinical trials display moderated efficiency

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The endogenous origin of DSIP remains uncertain

It is foundational