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97 Nicotine is a potent inducer of epithelial-mesenchymal transition by inhibiting the expression of E-cadherin and -catenin and can induce and facilitate transcription of mesenchymal genes such as fibronectin and vimentin in many cell lines

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The 2014 Surgeon General's Report found that cigarette smoking was responsible for an average of over 480,000 premature deaths in the United States each year from 2005 to 2009, of which almost 440,000 occurred because of active smoking (Ref

References: Harvard - CDC - CDC - NCBI - Online LIbrary - NCBI - Cancer Research UK -