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Impurities or batch variation can affect experimental reproducibility and data interpretation
B12 is often weekly to monthly for deficient patients, tapering as levels normalize
Local injections near the injury site often produce faster results than systemic administration through abdominal subcutaneous injection
A meta-analysis of four observational studies, following a total of 7,475 older individuals for 3 to 16 years, found a weak association between an elevation in vitamin B 12 of 50 pmol/L in blood and a reduction in fracture risk (114)
Once their TCIIs binding capacity is exceeded, the kidneys excrete excess B12 in the urine
This fact is relevant as transgenic mice overexpressing IGFBP-2 were resistant to developing obesity when fed with high fat diet [174], suggesting that this molecule could have a direct effect on preadipocyte differentiation
