There is great need for personalized, low cost, non-pharmacological interventions for this adult population with potential to treat multiple post-concussive symptoms, such as aerobic exercise
The practical version: take a daily liposomal glutathione or NAC supplement to maintain baseline levels, then book a monthly or biweekly IV session when you want a high-dose boost
Thus, trapping AP sites and blocking their repair by APE1 will result in cytotoxicity
For transfection, the resulting pbgst-ko plasmids ( pbgst-ko 1A and 1B ) were linearized using Kpn I/ Xba I and transfected independently into P
PMCID: PMC4937800) Jolivalt CG, Hurford R, Lee CA, Dumaop W, Rockenstein E, Masliah E (2010) Type 1 diabetes exaggerates features of Alzheimers disease in APP transgenic mice
The tripeptide structure of GSH suggest its potential role as a neuroactive molecule