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Plant Sci 163:4351 Twomey EC, Sobolevsky AI (2018) Structural mechanisms of gating in ionotropic glutamate receptors

Because it promotes the growth of new blood vessels one of the mechanisms proposed to explain its healing effects researchers have noted a theoretical risk related to cancer promotion that would need to be carefully evaluated in long-term human studies [4]

However, KYNA influences AMPAR activity predominantly through indirect mechanisms, namely its non-competitive allosteric inhibition of presynaptic 7nAChRs on glutamatergic terminals in mood-related circuits, leading to reduced glutamate release and downstream modulation of excitatory signalling [29, 30]

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Phenome-based approach identifies RIC1-linked Mendelian syndrome through zebrafish models, biobank associations and clinical studies