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CUL5 deficiency promotes megakaryopoiesis largely independent of the thrombopoietin/MPL pathway, instead relying on signaling through the common (c) and/or IL-3 (IL-3) receptors (81, 159)

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Diarrhea and constipation are also frequent, with each affecting 10 to 20 percent of individuals

It is important to note that the specific Klow combination itself has not been systematically evaluated in clinical studies, and any observed effects in research models should not be interpreted as evidence of safety or efficacy in humans or animals