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Several aldehydes, including formaldehyde, methylglyoxal (MGO), and glyoxal (GO), were found at significantly higher concentrations in heavily used devices

This may contribute the COPD pathology, inducing apoptosis, tissue damage as well as airway inflammation, since airway epithelial cells respond to increased ROS levels by producing cytokines/chemokines that attract inflammatory cells to the area of damage [5, 6, 21, 23, 24]

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