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Peripheral biomarkers and illness activity in bipolar disorder
Notice that GSH goes up for low estradiol values, reaches a peak and descends for high estradiol values Variation of GSH steady state depending on S In our model, we take the activation of GCL and GPX by estradiol to be 80%, which is a reasonable choice supported by the experimental and clinical data discussed above
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By targeting multiple pathways involved in appetite regulation, energy balance, and glucose metabolism, this combination could offer superior efficacy compared to single-agent therapies
It also reduced the rate of DPC apoptosis (cell death) and increased the ratio of Bcl-2/Bax (pro-survival markers)
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