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doi: 10.3389/fimmu.2021.696061 98 EdgeworthJGormanMBennettRFreemontPHoggN

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The ripoptosome phosphorylates mixed-lineage kinase domain-like protein (MLKL), and the phosphorylated MLKL activates mitochondrial ROS production

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However, despite the presence of NRF2 activating mutations in H2228, SLC7A11 expression in H2228 cells was lower than in PC9 cells and comparable to that of HCC44 cells