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Combined blockade of IL6 and PD-1/PD-L1 signaling abrogates mutual regulation of their immunosuppressive effects in the tumor microenvironment

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For example, GGT is involved in the biosynthesis of the phytoalexin camalexin by removing a -glutamyl group from glutathione-indole-3-acetonitrile in Arabidopsis (Su et al., 2011), in the conversion of the endogenous glutathione S -conjugate leukotriene C4 to leukotriene D4 in rats (Zhang et al., 2005

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10.1038/nature16187 12 GuptaS

doi: 10.1016/j.ifset.2021.102708