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ScienceDirect , Schizophrenia Bulletin , vol

A study of the frequency of 1183 T/C polymorphism of SOD2 in Japanese MASH patients revealed a higher incidence of the T/T genotype in the mitochondrial targeting sequence of this gene, resulting in the less effective targeting of Mn-SOD to mitochondria in these patients (Namikawa et al

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This resolution of ROS is crucial, as excess oxidative stress sustains nuclear factor kappa B (NFB)-driven inflammation and reinforces the M1 phenotype