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Thus, these disorders are accompanied by (a) signs of a mild inflammatory response as indicated by increased levels of C-reactive protein (CRP)

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Macrophages secrete cytokines, including interleukin-1 (IL-1), interleukin-6 (IL-6), fibroblast growth factor (FGF), PDGF, EGF, tumor necrosis factor (TNF), and TGF, which coordinate the migration of keratinocytes and fibroblasts to the wound (Sindrilaru and Scharffetter-Kochanek, 2013)

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This depletion can lead to increased vulnerability to oxidative damage, inflammation, and various chronic health conditions