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However, oxidative stress happens when the antioxidant defense system of body is overwhelmed by the production of ROS ( Figure 1 )

Moreover, the phenotype of the disease may evolve from episodic to more severe chronic cholestasis [62]

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The present review thus focuses on the role of GPX4 in the myeloid lineage, describing how increase in GPX4 expression can impact on myeloid cell homeostasis and transformation and whether GPX4 inhibition could represent an attractive strategy to treat AML patients

These results were corroborated and deepened by Marcello et al

Furthermore, chondrocyte ferroptosis is a type of regulated cell death driven by the accumulation of lipid peroxides and disruption of redox homeostasis, which severely affects cartilage integrity (Yao et al., 2021)