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Mouse studies demonstrate similar diet-driven changes, such as elevations in Actinobacteria ( Bifidobacterium , Adlercreutzia ), lactic acid bacteria ( Lactobacillus , Streptococcus ), and Verrucomicrobia ( Akkermansia muciniphila ) [174]

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Strategies such as gradual ascent, preacclimatization, descent, and several pharmacological agents (e.g., acetazolamide, methazolamide, dexamethasone, nifedipine, and sildenafil) are widely accepted as effective strategies for preventing and treating acute altitude illnesses

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Proteomic analysis was performed to identify differentially expressed proteins (DEPs), while metabolomic profiling was used to characterize metabolic changes