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Cleve Clin J Med 2020;87(3):153164

However, a 2025 HSS Journal systematic review (544 articles screened, 36 included 35 preclinical, 1 clinical) concluded that high-quality clinical evidence remains limited and use should be approached with caution

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Compromised liver function may affect these processes

It activates beta-3 adrenergic receptors located in fat tissue, which triggers lipolysis (fat breakdown) without sending any signals to the brains hunger centers in the hypothalamus