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Bioassay-guided isolation of the chloroform fraction yielded (E)-4-(3,4-dimethoxyphenyl) but-3-en-1-ol as the active compound (Ramadhan et al., 2020)

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Proposed mechanisms of MOTS-c: Activates AMPK Improves insulin sensitivity Enhances glucose utilization Increases metabolic flexibility Improves mitochondrial efficiency Supports exercise performance Why AMPK matters: AMPK is often called the body's metabolic master switch

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