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Additional research in Neural Plasticity has explored how methylcobalamin supports nerve regeneration and may reduce neuropathic pain through multiple neuroprotective mechanisms

It was also reported that these wounds had lower levels of pro-inflammatory markers such as tumor necrosis factor-alpha (TNF-alpha), matrix metalloproteinase-2 (MMP-2), and matrix metalloproteinase-9 (MMP-9), all of which are involved in inflammation and tissue remodeling

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Human umbilical vein endothelial cells (HUVECs) culture HUVECs purchased from BCRC (Hsinchu, Taiwan, ROC) were grown in M199 medium supplemented with 16% fetal bovine serum and 20% EGM-2 (Clonetics, USA)

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