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This paradoxical immune regulation underscores the need for precise modulation of necroptosis according to the treatment stage: leveraging its immune-stimulatory properties in the early stages while inhibiting its metastasis-promoting effects in the later stages [61]

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Stockout patterns also matter for price: when one or two vendors go OOS, the median per-mg price visible to buyers can drift upward simply because the cheapest vendor disappeared from the cohort

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