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The polysaccharide portion plays an indispensable role in Salmonella lipopolysaccharide-induced activation of NF-kappaB through human toll-like receptor 4

At the cellular level, vitamin B12 is involved in DNA synthesis and neuroprotection, acting as a cofactor for enzymes critical to these processes, such as methionine synthase and methylmalonyl-CoA mutase (72, 73)

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Anti-inflammatory effects of GHK-Cu GHK-Cu downregulates pro-inflammatory cytokines at the gene level

10 (2), e004434

In addition, the pro-oxidant/antioxidant effects of polyphenols and vitamins are context-dependent and moderate doses may be cardioprotective while supraphysiologic levels negatively affect the oxidative state or disrupt ROS-mediated signalling that is important for chemotherapy-induced killing of tumour cells (218)