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The synergistic insulin secretion produced by simultaneous GIP and GLP-1 receptor activation is mechanistically distinct from what amylin/GLP-1 combinations provide, and the SURPASS trial data in diabetic populations is among the strongest in the field

It increases fibroblast migration and dispersal, induces F-actin formation in fibroblasts, modulates angiogenesis, and enhances vascular expression of VEGFR2

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Volume: Per-injection volume (~0.1 mL) is well below the 1.01.5 mL comfort threshold for subcutaneous administration [9]

Both involve inflammation of the intestinal tract, but they differ in where and how the inflammation occurs

This suggests that additional sessions may produce further improvement, though the law of diminishing returns likely applies