In the nervous system, it plays a positive role in maintaining cognitive function and long-term nervous system health by reducing oxidative stress levels and decreasing nerve cell damage and apoptosis
Cheng M, Ren L, Jia X, Wang J, Cong B (2024) Understanding the action mechanisms of metformin in the gastrointestinal tract
Theres no denying the effectiveness of chiropractic care as a way to cope with pain and improve overall quality of life
STING activation reprograms tumor vasculatures and synergizes with VEGFR2 blockade
Further, our motif discovery analyses support the hypothesis that epigenetic remodelling in the USCs occurs primarily at AP-1-associated DARs in response to a self-limiting acute infection (resolved-accessible DARs), but that severe acute infection leading to chronic infection and inflammation (sensitized-accessible DARs) induces epigenetic remodelling not only at AP-1-associated DARs, but also at additional TF-associated DARs, such as those with Klf and Sox family motif sites
We found that cancer cells with -KG insufficiency exhibit cytosolic NADPH depletion because of defective FAO and TCA cycle, highlighting the importance of -KG in regulating NADPH homeostasis through mitochondrial metabolism
