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The short half-life of native GLP- 1-based therapy in the circulation (approximately two minutes after intravenous administration and one to five hours after subcutaneous administration) posed a problem during its early development [9]

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10.1007/s10787-019-00643-z [DOI] [PubMed] [Google Scholar] Hamaidi I., Kim S

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Dev Brain Res 117:4752 Keene AC, Appelbaum L (2019) Sleep in fish models