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The D-amino acid substitution preserves the spatial orientation of amino acid side chains needed for competitive binding to the FOXO4-p53 interaction surface, maintaining biological activity despite the non-natural backbone (PMID: 28340339)

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Factors that influence or control post-Golgi transport and translocation of HPV16 L2/vDNA remain largely uncharacterized

Hwang TL, Shaka AJ