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While side effects of GH administration in older adults include edema, arthralgias, and elevated blood glucose, data regarding the possible long-term effects on risk of fractures, cancer, cardiovascular disease, life expectancy, and mortality are lacking

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64 In serine proteases, neutrophil elastase (NE), cathepsin G and proteinase-3 destroy lung tissue by degrading ECM components, and induces epithelial cells and endothelial cells to release a variety of inflammatory factors to activate and chemoattract neutrophils to produce lung inflammation

doi: 10.1007/s00221-005-0220-x 168 PelizzoniIZacchettiDCampanellaAGrohovazFCodazziF

PubMed Scholar Bejar R, Stevenson K, Abdel-Wahab O