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Unlike other forms of regulated cell death, cuproptosis is characterized by the direct binding of reduced copper (Cu + ) to lipoylated proteins of the tricarboxylic acid (TCA) cycle, most notably dihydrolipoamide S-acetyltransferase (DLAT), together with destabilization of iron-sulfur (Fe-S) cluster proteins such as succinate dehydrogenase complex ironsulfur subunit B (SDHB) 164

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elegans , NR and NMN improved mitophagy through pink1 and Parkin homologs pdr-1 111,112

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Dihexa could perhaps be used to accelerate wound healing, promote improvement of circulation, and perhaps even enhance anabolic development and prevent muscular atrophy

2021, doi: 10.1021/acs.jmedchem.1c00565