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Animal model and experimental protocol Male C57BL/6 mice (8 weeks old) weighing 25 0.5 g were obtained from the Jackson Laboratory (Bar Harbor, ME)

383,384 Ferroptosis inhibitors targeting various pathways can reduce mitochondrial morphological changes and lipid peroxidation in muscle cells

Ethyl eicosapentaenoic acid (E-EPA or icosapent ethyl) is used to treat depression

16 Subcutaneous injection do not aspirateGuidance that aspiration is not required for routine subcutaneous injections

It is designed for rare disease trials where patient populations are often small and geographically dispersed, making multinational collaboration essential

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