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In this investigation, we initially identified oridonin as a direct covalent inhibitor of GSH, setting it apart from other drugs that disrupt ROS by targeting proteins both upstream and downstream of GSH

Xu X-M, Turanov AA, Carlson BA, Yoo M-H, Everley RA, Nandakumar R et al

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It is important to note that this mechanism, while biologically plausible, is not yet validated by large-scale controlled trials, and individual results vary considerably depending on baseline melanin levels, skin type, and dosage

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10.1080/19390211.2022.2120147 9 BaekJ.LeeM