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[1] Unlike the folic acid derivative leucovorin, folic acid is not clinically useful in offsetting the action of folate reductase inhibitors because it requires the enzyme dihydrofolate reductase for activation

GnRH agonists essentially turn off the menstrual cycle

For patients with genetic variants affecting B12 metabolism or impaired liver function, methylcobalamin is preferable

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This is likely an important, if not necessary, fundamental change in how we feed ourselves, but it is recognized that this could increase the prevalence of vitamin B12 deficiency because the vitamin is not found in plant-based foods (106, 107)

(B) CFU of WT, gGT , and gGTgGT H