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He pointed back to the several groups, including his own, that have reproduced the findings in cell cultures and rodents

Ajani has received honoraria from Lilly, Bayer, Novartis, Five Prime Therapeutics, Taiho Pharmaceutical, Genentech, and Roche, received research funding from Novartis, Bristol-Myers Squibb, Taiho Pharmaceutical, Roche/Genentech, MedImmune, Amgen, Lilly/ImClone, Merck, Delta-Fly Pharma, Gilead Sciences, and Takeda, and received travel accommodation expenses (not for this work) from Novartis, Bayer, and Five Prime Therapeutics

This safety profile in animal models provides some reassurance about the compounds fundamental tolerability, though extrapolation to humans requires appropriate caution

2005;19(6):403414 Sinzinger H, OGrady J

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