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10.1016/j.cell.2006.09.026 39 OlsonG

The global obesity epidemic and its associated metabolic disorders urgently require more effective therapeutic interventions, particularly multi-pathway targeting therapies

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Determinants of fibrosis progression and regression in NASH

mtDNA is 10 times more vulnerable to mutations and oxidative stress than nDNA due to a lack of histones protection, fewer repair enzymes, and increased susceptibility to supercoiling damage [94]

Lipids were extracted using the Folch procedure, and phosphorus was determined by a micromethod as described previously (7, 21)