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Furthermore, pharmacotherapeutic trials targeting monoaminergic systemssuch as SSRIs and bupropionhave shown modest efficacy in reducing depressive symptoms in alcoholics, though their benefits are often overshadowed by high placebo response rates and relapse risk (Agabio et al

It is unclear whether this patients diminished methotrexate clearance may have been affected by the fluid overload and the drug interaction with piperacillin plus tazobactam rather than decreased glucarpidase function

In contrast to ASCT2, ATB0,+ catalyzes unidirectional influx of substrates into cells [41]

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