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Regulatory scrutiny is increasing, and the landscape is shifting

The liver is the bodys primary detoxification organ, and glutathione plays a vital role in the livers ability to neutralize and eliminate toxins, free radicals, and waste products

However, the major toxicity of phosgene is believed to occur through acylation in which phosgene interacts with sulfhydryl, amine, and hydroxyl groups causing protein and lipid denaturation, disruption of membrane structure and interference with enzyme function

Chronic SSRI administration increases BDNF expression in the hippocampus, which is thought to mediate part of their delayed antidepressant effect