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However, the tobacco hornworm is capable of metabolizing nicotine from the tobacco plant and using nicotine as a defense against predators

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doi:10.1161/JAHA.117.006353 26

Y.s 2023 study, The experience of tobacco withdrawal symptoms among current smokers and ex-smokers in the general population: Findings from nationwide China Health Literacy Survey during 2018-19, Nicotine withdrawal affects over 61% of current smokers, primarily manifesting as cravings, restlessness, and anxiety

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