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Many people who quit smoking cold turkey without ample guidance might take up drinking or become addicted to a different drug

Failed Attempts to Quit: Individuals with addiction find it hard to quit despite having a strong desire to stop using tobacco

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Decades of research have focused on understanding how nicotine reward leads to drug addiction and what are the underlying brain circuits

Lower nicotine, nornicotine, and anabasine levels were also found to be statistically relevant in the double-homozygous clcnt2 -KO plants, with reductions ranging from 23.9 to 34.9% relative to the WT (Figure 7A)