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Because the pathways differ, the two are studied together for additive appetite effects

4 Novo Nordisk / NEJM CagriSema (cagrilintide + semaglutide)Trial data on the investigational dual GLP-1 + amylin combination CagriSema

clinical data is thin

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It is pharmacologically real, not a placebo step, but it is placed low so the gut can adapt before the effective doses arrive