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Recent prospectively designed studies have found higher WC increases CVD risk in older adults [27, 28], whilst meta-analyses demonstrate increased risk of incident dementia following obesity in mid-life, but a reduced risk when obesity is developed in older adulthood [29, 30]

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LCMS metabolomic analyses In vitro assay for succinate or glutarate release Experiments were performed as for the DTNB assay, but without the addition of 0.2 mM DTNB reagent

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