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Synergistic anticancer activity of arsenic trioxide with erlotinib is based on inhibition of EGFR-mediated DNA double-strand break repair
Psychiatry 54 MohrF.HubmannW.AlbusM.FranzU.HechtS.SchererJ.et al (2003)
Laboratory mice Biozzi ABH mice were originally purchased from Envigo and bred in-house under SPF conditions in individually ventilated cages in temperature controlled (21 C) animal facilities with 14/10 h light/dark cycles and a 55% humidity-controlled environment
Healthy colonic tissue shows minimal PepT1 expression
The 6-week intervention demonstrated significantly greater efficacy compared to longer durations (6 weeks), which showed diminished effects
These saponin components act through multiple targets and pathways, including anti-oxidative stress, anti-inflammatory, and anti-apoptotic mechanisms
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